Optimization of preparation process of Pollen Typhae dripping pills by AHP-EWM hybrid weighting method combined with Box-Behnken response surface methodology
- VernacularTitle:AHP-EWM混合加权法结合Box-Behnken响应面法优化蒲黄滴丸的制备工艺
- Author:
Fuqin ZHU
1
;
Luping SHI
2
;
Jiayi MA
1
;
Lingna CAI
1
;
Yan YU
1
Author Information
1. School of Pharmacy，Gansu University of Chinese Medicine，Lanzhou 730030，China
2. College of Traditional Chinese Medicine，Xinjiang Second Medical College，Xinjiang Karamay 834000，China
- Publication Type:Journal Article
- Keywords:
Pollen Typhae dripping pills;
AHP-EWM hybrid weighting method;
Box-Behnken response surface method;
total flavonoids from Pollen Typhae;
Process optimization
- From:
China Pharmacy
2026;37(18):2376-2381
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To optimize the preparation process of Pollen Typhae dripping pills.METHODS Using appearance morphology， roundness， tailing phenomenon， adhesion condition， friability， and total flavonoids content of Pollen Typhae as evaluation indicators， the analytic hierarchy process-entropy weight method （AHP-EWM） hybrid weighting method was employed to determine the weight coefficients of each indicator and calculate the comprehensive score as the response value. The effects of matrix type and ratio， drug-to-matrix ratio， and condensation temperature on the forming process of dripping pills were respectively investigated， through single-factor experiments and Box-Behnken response surface methodology and the optimal process was optimized and validated. The cumulative dissolution rate of Pollen Typhae dripping pills within 150 min was determined and compared with that of total flavonoid extract from Pollen Typhae .RESULTS The optimal preparation process for Pollen Typhae dripping pills was determined as follows： the ratio of PEG4000 to PEG6000 was 2∶1， the drug-to-matrix ratio was 1∶2， and the condensation temperature was 17.5 ℃. The measured average comprehensive score of dripping pills prepared under these conditions was 9.208 （RSD＝0.91%， n ＝3）， with a relative error of 0.83% compared to the predicted value of 9.285. The release mechanism of Pollen Typhae dripping pills was Fickian diffusion controlled deceleration release. The initial dissolution rate was fast， and the dissolution rate decreased in the middle and later stages. The total flavonoid extract from Pollen Typhae was released rapidly in the initial dissolution stage and quickly entered the plateau phase. Their maximum dissolution rates were 95.96% and 84.07%， respectively.CONCLUSIONS The optimized preparation process for Pollen Typhae dripping pills was stable and reliable. The dissolution rate of Pollen Typhae dripping pills prepared by optimized process was higher than that of the total flavonoid extract from Pollen Typhae .
