Study on the hemolysis, allergenicity and local irritancy of fibrauretine injection
10.12206/j.issn.2097-2024.202506020
- VernacularTitle:注射用黄藤素的溶血性、过敏性和局部刺激性研究
- Author:
Gaoming LYU
1
;
Huanhuan ZHENG
2
;
Changgen LI
1
Author Information
1. Anhui Fuyang Food and Drug Inspection and Testing Center, Fuyang 236000, China.
2. Pharmacy Department of Funan County Hospital, Funan 236300, China.
- Publication Type:Originalarticles
- Keywords:
fibrauretine for injection;
allergic;
hemolytic;
irritant
- From:
Journal of Pharmaceutical Practice and Service
2026;44(9):472-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application safety of fibrauretine injection through hemolytic test, active systemic anaphylaxis（ASA）test and local irritation test. Methods Routine visual observation and spectrophotometry were used to detect its hemolysis; the ASA test on guinea pigs was conducted to observe the allergenicity of the drug; the auricular vein irritation test and quadriceps femoris muscle irritation test on rabbits were performed to evaluate the irritancy of the drug. Results Fibrauretine injection induced hemolysis in rabbit red blood cells, did not cause allergic reactions in guinea pigs, exerted mild to moderate irritation on the auricular veins of rabbits, and showed no irritant effect on the quadriceps femoris of rabbits. Conclusion Fibrauretine injection had certain hemolytic properties and vascular irritancy. Special attention should be paid to safety inspections during the production and clinical application of this drug.
