Research progress on acne pathogenesis and medicine intervention based on mTOR signaling pathway
10.12206/j.issn.2097-2024.202411019
- VernacularTitle:基于雷帕霉素靶蛋白信号通路的痤疮病理机制及其药物干预研究进展
- Author:
Zhiwei LIU
1
;
Zhenlin HU
1
;
Xiaolei DING
1
;
Juan WANG
1
Author Information
1. School of Medical, Shanghai University, Shanghai 200444，China.
- Publication Type:Reviews
- Keywords:
mTOR;
acne;
sebaceous glands;
lipogenesis;
therapy
- From:
Journal of Pharmaceutical Practice and Service
2026;44(9):437-441
- CountryChina
- Language:Chinese
-
Abstract:
The mechanistic target of rapamycin （mTOR） is an important signaling functions as a central regulator of cell growth, proliferation and metabolism. Dysregulated mTOR signaling has been implicated in various inflammatory and hyperproliferative skin conditions. Emerging data suggest that mTOR signaling is tightly associated with acne pathogenesis. The regulatory mechanisms of the mTOR signaling pathway in the pathogenesis of acne were summarized and the current progress of therapeutic targeting mTOR pathway for acne were discussed in this paper.
