A case report of neurosyphilis diagnosed at General hospital of Songinokhairkhan district
- VernacularTitle:СХД-ийн Нэгдсэн эмнэлэгт оношлогдсон мэдрэлийн тэмбүүгийн тохиолдол
- Author:
Bilguun N
1
;
Chantsaldulam G
2
;
Tserentogtokh D
2
;
Davaajargal O
1
;
Sarangerel B
2
;
Oyuntuul G
2
Author Information
1. General hospital of Songinokhairkhan district, STI clinic
2. General hospital of Songinokhairkhan district, Inpatient clinic of Neurology
- Publication Type:Case Reports
- Keywords:
Neurosyphilis;
Cerebrospinal fluid (CSF);
Rapid plasma reagin (RPR);
Treponema pallidum hemagglutination assay-TPHA
- From:
Mongolian Journal of Health Sciences
2026;94(4):141-143
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Neurosyphilis is a severe manifestation of Treponema pallidum infection that may occur at any stage, particularly in cases of inadequate treatment or follow-up.
Case Presentation:We report a case of a 55-year-old male with a prior history of treated syphilis who presented with progressive neuropsychiatric symptoms, including memory impairment, disorganized speech, and behavioral changes. Serial serological testing revealed a rising rapid plasma reagin (RPR) titer from 1:2 to 1:32 over time. Cerebrospinal fluid (CSF) analysis demonstrated elevated protein levels and a positive Treponema pallidum hemagglutination assay (TPHA 1:80), confirming the diagnosis of neurosyphilis despite a negative VDRL test in CSF. The patient was initially treated with ceftriaxone, followed by definitive therapy with intravenous benzylpenicillin for 14 days. Subsequent follow-up showed a gradual decline in RPR titers (1:32 to 1:1) along with clinical improvement.
Conclusion:This case underscores the importance of adequate post-treatment surveillance and highlights the need to consider neurosyphilis in patients presenting with neuropsychiatric symptoms and rising serological titers, even in the absence of positive CSF VDRL findings.
- Full text:202610012307573639029_141-143_СХД-ийн Нэгдсэн эмнэлэгт оношлогдсон мэдрэлийн тэмбүүгийн тохиолдол.pdf
