A rare case of basal cell carcinoma coexisting with schwannoma
- VernacularTitle:Суурь эсийн хорт хавдар, арьсны шванноматай хавсарч илэрсэн нэн ховор тохиолдол
- Author:
Nomin O
1
;
Munkhjin E
1
;
Undram S
1
Author Information
1. Sundra dermatology clinic
- Publication Type:Case Reports
- Keywords:
Coexisting tumor;
Schwann cells;
Skin biopsy;
Immunohistochemistry
- From:
Mongolian Journal of Health Sciences
2026;94(4):137-140
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Basal cell carcinoma stands as the most prevalent cutaneous malignancy, originating from the basal cells of the epidermis. Approximately 4 million new cases are diagnosed globally annually. In contrast, schwannoma is a rare benign nerve sheath tumor arising from Schwann cells. The simultaneous occurrence of these two tumors within a single lesion is exceedingly uncommon. We present a rare case of basal cell carcinoma coexisting with cutaneous schwannoma.
Case Presentation:A 68-year-old European male patient presented to Sundara Dermatology Clinic in April 2025 with a complaint of a persistent facial lesion that had not healed. The lesion initially manifested in June 2024 as a small, asymptomatic lesion, which the patient disregarded, attributing it to minor trauma during shaving. Recently, the lesion has exhibited an increase in size and occasional bleeding. Upon the physical examination, a round to oval-shaped, elevated papular lesion with central ulceration and crusting was observed on the right nasolabial fold.
Diagnosis:A skin biopsy was conducted to ascertain the diagnosis. Histopathological examination indicated the presence of basal cell carcinoma in conjunction with schwannoma or neuroma, necessitating a differential diagnosis. Immunohistochemical analysis employing markers such as S100, BCL2, P63, CD10, and actin was performed. Upon analyzing the histological and immunohistochemical findings, the final diagnosis was confirmed as Basal cell carcinoma coexisting with schwannoma.
Treatment:Surgical excision is the standard treatment for both basal cell carcinoma and schwannoma. The patient was advised accordingly and underwent complete surgical removal of the tumor. No recurrence has been observed during postoperative follow-up.
Conclusion:The coexistence of basal cell carcinoma and cutaneous schwannoma within a single lesion is exceedingly rare. Clinically, basal cell carcinoma frequently mimics other dermatological conditions, necessitating meticulous differentiation. It is imperative to emphasize the paramount importance of skin biopsy and immunohistochemistry in the differential diagnosis and optimal treatment selection.
- Full text:202610012307310143728_137-140_Суурь эсийн хорт хавдар арьсны шванноматай хавсарч илэрсэн нэн ховор тохиолдол.pdf
