A Case report: Chronic Eosinophilic Leukemia
- VernacularTitle:Архаг эозинофилийн лейкеми өвчний эмнэлзүйн ховор тохиолдол
- Author:
Erdenechimeg Ch
1
;
Baljinyam P
2
;
Undram S
3
;
Tsogzol G
1
;
Khandsuren B
4
Author Information
1. Outpatient Department, National Dermatology Center
2. Department of Hematology and Bone Marrow Transplantation Center, FCHM
3. Sundara Dermatology Clinic
4. Department of Dermatology, School of Medicine, MNUMS
- Publication Type:Case Reports
- Keywords:
Chronic eosinophilic leukemia;
Blast cell;
Imatinib;
Pruritus
- From:
Mongolian Journal of Health Sciences
2026;94(4):112-115
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Chronic eosinophilic leukemia (CEL) is a rare, slowly progressive hematologic malignancy characterized by clonal proliferation of eosinophils in the bone marrow due to underlying genetic mutations. Persistent eosinophilia (>1.5 x 10⁹/L) for 1–6 months is a key diagnostic criterion. The presence of the FIP1L1::PDGFRA fusion gene and increased blast or abnormal cells in the bone marrow further supports the diagnosis.
Case presentation:A 63-year-old male presented with symptoms of dry skin, pruritus, skin rash, enlargement of cervical, axillary, and inguinal lymph nodes, headache, and edema. According to the medical history, the disease began 4 years earlier with pruritus in the lower legs and progressed over the past 2 years with worsening skin rash. Complete blood count revealed eosinophilia of 48.6%. Based on leukogram, myelogram, skin histopathology, and cytogenetic analysis performed in China, a diagnosis of chronic eosinophilic leukemia was established. The patient responded well to treatment with imatinib and hydroxycarbamide.
Conclusion:Clinical manifestations of chronic eosinophilic leukemia are often nonspecific and may be misdiagnosed as dermatological conditions. Therefore, cytogenetic analysis (including FISH), leukogram, myelogram, and skin histopathological examination play a crucial role in accurate diagnosis.
- Full text:202610012303491496122_112-115_Архаг эозинофилийн лейкеми өвчний эмнэлзүйн ховор тохиолдол.pdf
