Mechanisms and therapeutic advances of antimicrobial peptides in periodontal regeneration
10.12016/j.issn.2096-1456.202550593
- Author:
LI Lingjun
1
;
ZHANG Miaomiao
2
,
3
;
YAN Fuhua
2
,
3
;
WANG Xiang
4
Author Information
1. Department of Periodontology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University 2Department of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University.
2. Department of Periodontology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University
3. Department of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University
4. Department of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University 2Research Institute of Stomatology, Nanjing University.
- Publication Type:Review
- Keywords:
periodontitis;
antimicrobial peptides;
antibacterial;
periodontal tissue regeneration;
immuno⁃modulation;
angiogenesis;
bone regeneration;
angiogenesi-osteogenesis coupling;
clinical translation
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2026;34(10):1021-1032
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis leads to progressive destruction of periodontal supporting tissues, and conventional anti-infective therapies often fail to simultaneously achieve infection control and tissue regeneration. Due to the increasing threat of antibiotic resistance, the development of novel bioactive molecules with both anti-infective and pro-regenerative properties has become a focus of research. Antimicrobial peptides (AMPs), characterized by multi-target antimicrobial mechanisms and immunomodulatory functions, have attracted considerable attention in periodontal tissue regeneration. Current evidence indicates that AMPs not only inhibit periodontal pathogens and biofilm formation, but they also regulate macrophage polarization, suppress inflammatory cytokine release, and activate signaling pathways, such as Wnt/β-catenin and MAPK/ERK. These effects promote osteogenic differentiation of periodontal ligament stem cells and bone marrow mesenchymal stem cells, while enhancing angiogenesis through VEGF induction, thereby establishing a favorable immune microenvironment for periodontal regeneration. Despite these promising findings, the in vivo stability, dosage safety, and long-term mechanisms of AMPs remain to be fully elucidated. Future studies should focus on clarifying the molecular mechanisms by which AMPs regulate the periodontal immune microenvironment and angiogenesis-osteogenesis coupled regeneration. In addition, integrating structural optimization, advanced delivery systems, and artificial intelligence-assisted peptide discovery may accelerate the development and clinical translation of novel antimicrobial peptides.
- Full text:2026093011043722859抗菌肽在牙周组织再生中的作用机制及应用进展.pdf
