Characterization and Drug Release Kinetics of a Ceftriaxone-delivery system based on Natural Zeolite
- VernacularTitle:Байгалийн цеолитод суурилсан цефтриаксон хүргэлтийн системийн шинж чанар, чөлөөлөгдөх кинетикийг судалсан дүн
- Author:
Altantogos M
1
;
2
;
Ochirkhuyag B
2
;
Sarangerel D
3
Author Information
1. Department of Medical Chemistry, School of Biomedicine, MNUMS
2. Department of Chemical and Biological engineering, School of Engineering and Technology, NUM
3. Department of Chemistry, School of Arts and Sciences, NUM
- Publication Type:Journal Article
- Keywords:
Natural zeolites;
drug delivery system;
clinoptilolite;
zero order release kinetic;
release mechanism
- From:
Mongolian Journal of Health Sciences
2026;93(3):85-90
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Growing bacterial resistance remains a critical global health threat, underscoring the need for precision antibiotic delivery. Our research addresses this by developing CFT@MNZ-HDTMA for ceftriaxone (CFT) antibiotic. By utilizing a natural zeolite framework, this system optimizes the delivery and release kinetics of CFT, aiming to maximize clinical outcomes while minimizing adverse effects.
Aim:The primary aim is to characterize the physicochemical properties of the CFT@MNZ-HDTMA system and elucidate its CFT release mechanisms through kinetic analysis. The study utilizes XRD and FTIR spectroscopy to determine the composite’s structural and chemical integrity. Furthermore, it evaluates the rate and consistency of drug release to establish a predictable kinetic model and explain the interaction between the antibiotic and the modified zeolite matrix.
Materials and Methods:CFT delivery system was developed through the systematic modification of MNZ, with its structural and chemical properties characterized using XRD and FT-IR spectroscopy. The in vitro release kinetics of CFT from the carrier matrix were evaluated at 37°C over a 24-hour period, with drug concentrations quantified via UV-Vis spectrophotometry.
Result:CFT was successfully adsorbed onto the surface of the MNZ-HDTMA. The subsequent release profiles demonstrated that CFT discharge remained constant over time and exhibited concentration-independent behavior, characteristic of zero-order kinetics. This mechanism ensured a controlled and sustained release of the therapeutic agent, facilitating a prolonged delivery window suitable for enhancing clinical efficacy.
Conclusion:Natural zeolite from the Tushleg deposit was processed through systematic modification to develop the CFT@MNZ-HDTMA drug delivery system. XRD and FT-IR analyses confirmed that the zeolite’s crystalline structure remained stable, while successfully demonstrating that the CFT was adsorbed onto the surface of the adsorbent through ionic interactions. Kinetic studies revealed that CFT is released from the system following a zero-order model (R2=0.9804), indicating a constant release rate. This proves the system’s practical significance in sustaining therapeutic effects and minimizing potential side effects.
- Full text:202609270140176167311_85-90_Байгалийн цеолитод суурилсан цефтриаксон хүргэлтийн системийн шинж чанар чөлөөлөгдөх кинетикийг судалсан дүн.pdf
