Discrepancies between pre- and post-endoscopic submucosal dissection clinicopathological findings in early gastric cancer
- VernacularTitle:Ходоодны хорт хавдрыг дурангаар хуулах эмчилгээний өмнөх ба дараах эмнэлзүй-эмгэг судлалын зөрүүг судалсан үр дүн
- Author:
Amarbat B
1
;
2
;
Anujin R
2
;
Oyuntsetseg Kh
1
;
Bira N
1
;
Erdene-Ochir Ya
2
Author Information
1. Department of Gastroenterology, School of Medicine, MNUMS
2. National Cancer Center, Ulaanbaatar, Mongolia
- Publication Type:Journal Article
- Keywords:
Endoscopy;
Diagnosis;
Treatment;
Adenocarcinoma;
Dysplasia
- From:
Mongolian Journal of Health Sciences
2026;96(6):168-173
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:In the treatment of early gastric cancer, patients suitable for endoscopic submucosal dissection (ESD) are selected on the basis of endoscopic findings and biopsy results, while the final diagnosis is confirmed by examination of the resected specimen.
Aim:To examine the discrepancies between clinical and pathological findings before and after ESD.
Materials and Methods:We retrospectively identified 335 lesions treated by ESD for early gastric cancer at the National Cancer Center between 2020 and 2025, compared the endoscopic, biopsy and pathological findings, and identified the factors associated with discrepancy.
Result:At least one of the three pre-treatment parameters was discordant in 175 lesions (52.2%). Of the 249 lesions judged to be ulcer-free on endoscopy, 51 (20.5%) were ulcerated histologically, while 28 lesions were overestimated (P<0.05). Underestimation of ulceration was more likely in lesions located in the upper or middle third of the stomach (OR 2.17, 95% CI 1.22–3.99) and in lesions measuring ≥20 mm (OR 1.68, 95% CI 1.00–2.84). Of the 110 lesions diagnosed as high-grade dysplasia on biopsy, 36 (32.7%) contained adenocarcinoma in the resected specimen, one of which was of undifferentiated type. Of the remaining 18 undifferentiated lesions, 6 (33.3%) had been diagnosed as differentiated type before treatment. Submucosal and lymphovascular invasion were associated with a tumor size of ≥20 mm (OR 3.58 and 3.15) and undifferentiated histology (OR 4.47 and 7.56); all P<0.01.
Conclusion:A significant discrepancy was observed between the pre- and post-ESD clinicopathological findings.
- Full text:202609270051142773029_Ходоодны хорт хавдрыг дурангаар хуулах эмчилгээний өмнөх ба дараах.pdf
