Liver-targeted therapies for improving mild cognitive impairment： Mechanism of action and treatment strategies
- VernacularTitle:靶向肝脏改善轻度认知障碍的作用机制与治疗策略
- Author:
Jinyu LI
1
;
Heng JIANG
2
;
Duiping FENG
3
;
Jisheng NIE
2
Author Information
- Publication Type:Review
- Keywords: Cognitive Dysfunction; Liver-Brain Axis; Therapeutics
- From: Journal of Clinical Hepatology 2026;42(8):1996-2000
- CountryChina
- Language:Chinese
- Abstract: Mild cognitive impairment （MCI） is a critical precursor stage of Alzheimer’s disease， and the development of MCI is closely associated with liver function. As a core metabolic organ， the liver regulates cognitive function through the liver-brain axis. Epidemiological studies have shown the association between liver function parameters and MCI. The liver affects cognitive function by clearing peripheral β-amyloid （mainly via the PPARα-LRP-1 pathway）， secreting hepatic factors such as FGF21 and sEH to modulate neuronal energy metabolism， and mediating oxidative stress and systemic inflammatory responses. Anti-inflammatory/antioxidant measures， dietary pattern adjustments， and aerobic exercise are currently effective strategies for regulating liver function and mitigating mild cognitive impairment. This article systematically reviews the role and mechanism of the liver-brain axis in MCI， in order to provide new perspectives for developing liver-targeted therapies for cognitive impairment.
