Application value of human leukocyte antigen gene testing in screening for idiosyncratic drug-induced liver injury
- VernacularTitle:人类白细胞抗原基因检测在特异质型药物性肝损伤筛查中的应用
- Author:
Xueyu XIANG
1
;
Tongdong SHI
1
Author Information
- Publication Type:Review
- Keywords: Chemical and Drug Induced Liver Injury; HLA Antigens; Genomics
- From: Journal of Clinical Hepatology 2026;42(8):1990-1995
- CountryChina
- Language:Chinese
- Abstract: The pathogenesis of idiosyncratic drug-induced liver injury （IDILI） remains unclear due to the rarity and unpredictability of IDILI and a lack of effective in vitro and in vivo models. Recent studies have shown that human leukocyte antigen （HLA） gene polymorphisms are significantly associated with the susceptibility to IDILI induced by various drugs. This article systematically reviews the latest research advances in HLA gene testing for IDILI， with a focus on the association between specific HLA gene loci and genetic susceptibility to drug-induced liver injury caused by commonly used drugs， in order to highlight the significance of HLA gene testing in IDILI screening.
