Role and mechanism of liver sinusoidal endothelial cells in acetaminophen-induced liver injury
- VernacularTitle:肝窦内皮细胞在对乙酰氨基酚所致肝损伤中的作用及其机制
- Author:
Lu PENG
1
;
Qi ZHANG
2
;
Xinxin ZHU
3
;
Aijuan QU
2
;
Yan WANG
1
Author Information
- Publication Type:Review
- Keywords: Liver Sinusoidal Endothelial Cell; Acetaminophen; Chemical and Drug Induced Liver Injury
- From: Journal of Clinical Hepatology 2026;42(8):1985-1989
- CountryChina
- Language:Chinese
- Abstract: Liver injury due to acetaminophen overdose is one of the main causes of acute liver failure， with a complex pathogenesis. In this process， liver sinusoidal endothelial cell （LSEC） injury is a key early event jointly mediated by factors such as oxidative stress， cell apoptosis， and imbalance between fibrinolysis and coagulation. Subsequent LSEC dysfunction further induces sinusoidal microcirculatory disturbances， amplifies the inflammatory response， impairs the regeneration and repair abilities of the liver， and finally causes hepatocyte necrosis. This article systematically elaborates on the critical role and molecular mechanism of LSEC in acetaminophen-induced liver injury， in order to provide a theoretical basis for novel therapeutic strategies and research directions.
