Mechanism of action of T cell senescence in the progression of liver fibrosis to liver cirrhosis in elderly patients with chronic hepatitis B
- VernacularTitle:T细胞衰老在老年慢性乙型肝炎患者肝纤维化向肝硬化进展中的作用机制
- Author:
Ting WANG
1
;
Chengkai YANG
1
;
Xu XU
1
Author Information
- Publication Type:Review
- Keywords: Hepatitis B， Chronic; Hepatic Fibrosis; Liver Cirrhosis; T-Lymphocytes; Cellular Senescence
- From: Journal of Clinical Hepatology 2026;42(8):1980-1984
- CountryChina
- Language:Chinese
- Abstract: Liver fibrosis is a key pathological process in the transition from chronic liver disease to cirrhosis， especially in elderly patients with chronic hepatitis B， and this process is characterized by rapid progression and poor prognosis. T cell function gradually declines with aging， and T cell senescence is recognized as a key immunological mechanism accelerating the progression of liver fibrosis. Current studies have shown that senescent T cells promote the transition from liver fibrosis to liver cirrhosis by altering the liver inflammatory microenvironment， modulating the activity of fibrosis-related cells， and impairing immune surveillance function. This article systematically reviews the molecular mechanisms of T cell senescence and its role in the progression of liver fibrosis in elderly patients with chronic hepatitis B， as well as novel therapeutic approaches targeting immunosenescence with reference to the latest immunological findings and stem cell-based therapeutic strategies， so as to provide theoretical support for precise intervention for such patients.
