Evaluation of the effectiveness of incorporating two doses of varicella vaccine into the immunization program for the prevention and control of varicella in Jinshan District, Shanghai
10.3969/j.issn.1006-2483.2026.05.010
- VernacularTitle:2剂次水痘疫苗纳入免疫规划对上海市金山区水痘发病防控效果评价
- Author:
Jingjing WANG
1
;
Yueyue LIU
1
;
Miao MA
1
;
Ru GUAN
1
;
Jie ZHOU
1
Author Information
1. Jinshan District Center for Disease Control and Prevention (Jinshan District Health Supervision Institute) Shanghai 201599, China
- Publication Type:Journal Article
- Keywords:
Varicella;
Incidence;
Vaccine;
Epidemiological characteristics;
Interrupted time series
- From:
Journal of Public Health and Preventive Medicine
2026;37(5):46-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of incorporating two doses of varicella vaccine into the immunization program in Shanghai on the incidence of varicella, age-specific incidence, and varicella outbreaks in kindergartens and schools in Jinshan District, and to assess its prevention and control effects. Methods Descriptive epidemiological methods were used to analyze and compare the population distribution characteristics and the occurrence of varicella outbreaks before (2013-2017) and after (2018-2024) the implementation of the strategy. Interrupted time series (ITS) design and its segmented regression model were used to analyze the changes in the incidence of varicella in the two stages before and after the implementation of the vaccination of two doses of varicella vaccine, and to evaluate the short-term and long-term preventive and control effects of the strategy. Results After the incorporation of two doses of varicella vaccine into the immunization program, the average annual incidence of varicella in Jinshan District decreased from 82.19/100 000 (2013-2017) to 53.51/100 000 (2018-2024). The interrupted time series analysis showed that after the implementation of the strategy, the slope change in the incidence of varicella was -10.20/100 000 (t=-2.38, P=0.04), and the overall trend was downward (slope β1+β3= -8.34/100 000). Except for the 30-49 years old group, the incidence rates in all other age groups decreased to varying degrees. Among them, the 5-9 years old group had a better vaccine efficacy (VE) of 52.23% (95% CI: 49.07-60.65), followed by the 10-14 years old group. The number of potential varicella outbreaks and cluster outbreaks in nurseries, kindergartens, and schools across the district dropped significantly. Conclusion Incorporating two doses of varicella vaccine into the immunization program can effectively reduce the incidence of varicella and the number of varicella outbreaks in kindergartens and schools, which is of great significance for the prevention and control of varicella.
