Differentiation and Treatment of Cancer Cachexia Based on the Pathogenesis of "Earth Congestion and Wood Constraint， Internal Accumulation of Turbid Toxin"
10.13288/j.11-2166/r.2026.18.012
- VernacularTitle:基于脾壅肝郁、浊毒内蕴病机探析肿瘤恶病质的辨治
- Author:
Lingmin QIAN
1
;
Dongxin TANG
1
;
Jiao WU
2
;
Bing YANG
1
;
Wenyu WU
2
Author Information
1. Guizhou University of Traditional Chinese Medicine，Guiyang，550005
2. First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
tumor;
cachexia;
turbid toxin;
tumor microenvironment;
earth congestion and wood constraint
- From:
Journal of Traditional Chinese Medicine
2026;67(18):1982-1986
- CountryChina
- Language:Chinese
-
Abstract:
Based on the pathogenesis of earth congestion and wood constraint， internal accumulation of turbid toxin， this paper analyzes the evolution characteristics and therapeutic methods of the traditional Chinese medicine （TCM） pathogenesis of cancer cachexia. Based on the progressive process of cancer cachexia， characterized by earth congestion， wood constraint， turbidity accumulation， and disease progression， earth congestion is considered as the initiating factor， which initially attacks the body and leads to qi constraint and stagnation. Over time， middle jiao （焦） fails to transport properly， and the internal accumulation of turbid toxin hinders the ascent and descent of qi. Consequently， earth congestion and wood constraint mutually affect each other， causing the turbid toxin to become increasingly profound and persistent throughout the entire course of cancer cachexia. Combined with the progressive evolution process of the disease， it is proposed that in the early stage， treatment should focus on fortifying the spleen， resolving stagnation， and unblocking fu （腑） organs to restore the transportation and transformation functions of the spleen and stomach， increase appetite， and promote muscle recovery. In the middle stage， harmonizing the liver and spleen and smoothing the qi movement should be taken as the key therapeutic principles to reverse the disease progression. In the late stage， treatment should focus on resolving turbid toxin and unblocking stagnated stasis in the collaterals to halt the progression of the disease and prolong the survival period of cancer patients.
