Differentiation and Treatment of Coronary Heart Disease from the Perspective of "Guarding the Channel Passages" Based on Circadian Rhythm
10.13288/j.11-2166/r.2026.18.011
- VernacularTitle:基于昼夜节律探讨从“守经隧”辨治冠心病
- Author:
Jingjing ZHAO
1
;
Yuanyuan CHEN
1
;
Lanlan LI
1
;
Xiaoqing ZHANG
1
;
Ran ZHAO
1
;
Shujuan XU
1
;
Han PENG
1
;
Lingmei LI
2
;
Hao GUO
1
;
Jianhua FU
1
Author Information
1. Xi yuan Hospital，China Academy of Chinese Medical Sciences/National Clinical Research Center for Chinese Medicine Cardiology，Beijing，100091
2. Kunshan Hospital of Traditional Chinese Medicine，Jiangsu Province
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
circadian rhythm;
qi;
vessels;
blood;
channel passages;
timed medication
- From:
Journal of Traditional Chinese Medicine
2026;67(18):1977-1981
- CountryChina
- Language:Chinese
-
Abstract:
Coronary heart disease （CHD） has a distinct circadian rhythmicity in its onset， which is closely related to the waxing and waning of qi and blood in the channel passages of the human body. Grounded in the circadian rhythm theory of "correspondence between heaven and humankind"， this paper explores the pathogenic evolution rules of qi-blood disharmony， channel obstruction， interacting as cause and effect with circadian rhythm disorders in CHD. Clinically， CHD can be observed to attack in the early morning， at night， in the afternoon， and at fixed or unfixed circadian intervals. The pathogenesis rhythms at different time nodes can correspondingly reflect the susceptibility tendencies and pathological stress responses of the human body to core pathogeneses such as yang deficiency with cold congelation， yin deficiency with yang floating， qi and yin deficiency， and liver constraint with qi stagnation under specific temporal states. Treatment should be adapted to the season and time， regulating yin and yang in accordance with biological rhythms. It is recommended to regulate qi during the daytime by promoting ascending and dispersing to unblock the channel passages， and select the appropriate timing for administration to harness natural timing. At the Mao （卯） hour， yang ascends while yin descends， and taking medication at this time conforms to the ascending of yang qi. At the Wu （午） hour， the heart meridian is active， and taking medication at this time warms the channel passages and assists heart yang， which can be treated with modified Buzhong Yiqi Decoction （补中益气汤） or Shengyang Yiwei Decoction （升阳益胃汤）. At night， blood should be harmonized， when the channel passages are unblocked through nourishing， restraining， and searching， with Lianmei Decoction （连梅汤） combined with Dahuang Zhechong Pill （大黄䗪虫丸）. Following the temporal rhythm， the focus is put on the transitional time of day and night and the four seasons to treat disease before it arises， resonating and corresponding with the natural rhythm.
