Pathogenesis Evolution and Staged Syndrome Differentiation and Treatment of Amyotrophic Lateral Sclerosis from the Perspective of Emotional Latent Pathogen
10.13288/j.11-2166/r.2026.18.010
- VernacularTitle:情志伏邪病机学说视域下肌萎缩侧索硬化的病机演变与分期辨治
- Author:
Jiamin LI
1
;
Xianghua QI
1
;
Jing TENG
2
Author Information
1. Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan，250011
2. Shandong University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
amyotrophic lateral sclerosis;
latent pathogen;
emotions;
atrophy
- From:
Journal of Traditional Chinese Medicine
2026;67(18):1973-1976
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theory of "emotional factors causing atrophy" and latent pathogen from the Inner Canon of Yellow Emperor （《黄帝内经》）， the theory of latent emotional pathogens is introduced into the study on the pathoge-nesis of amyotrophic lateral sclerosis （ALS）. It is believed that internal emotional injury can lurk in the body， gradually accumulating into momentum and becoming the internal driving force in the evolution of ALS. The pathogenesis can be summarized into four stages of "latent， accumulation， transformation， and manifestation"， revealing the evolutionary process of the disease from emotional internal injuries， through qi mechanism imbalance and qi transformation disorder， to essence depletion and physical damage. Based on this， an early identification approach guided by "observing the mechanism to recognize the disease" and a staged differentiation and treatment strategy are proposed. During the initial stage， it is recommended to regulate the spirit， soothe the liver， regulate qi， and harmonize the center. During the latent stage， the focus is put on soothing the liver and fortifying the spleen， supplementing qi， resolving phlegm， and promoting blood circulation. During the evolution stage， the method of tonifying the spleen and kidney， replenishing essence and nourishing blood， resolving phlegm and unblocking collaterals can be used. During the active stage， it is advised to supplement qi and raise the sunken， tonify the spleen and kidney， while taking into account lung qi and collaterals.
