Key influencing factors and improvement strategies of prognosis in lung transplant recipients
10.12464/j.issn.1674-7445.2026044
- VernacularTitle:肺移植受者预后关键影响因素及改善策略
- Author:
Mengting ZHANG
1
;
Xiaoshan LI
1
;
Ting QIAN
1
;
Lin MAN
1
;
Min XIONG
1
;
Shiqiang XUE
1
;
Yetian QIAO
1
;
Lin ZHU
1
;
Jingyu CHEN
1
;
Bo WU
1
Author Information
1. Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Department of Lung Transplant Center, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
- Publication Type:ReviewArticle
- Keywords:
Lung transplantation;
Prognosis;
Donor-related factor;
Recipient-related factor;
Rejection;
Primary graft dysfunction;
Chronic lung allograft dysfunction;
Infection
- From:
Organ Transplantation
2026;17(5):875-882
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, remarkable advances have been made in lung transplantation regarding donor evaluation, perioperative support, and immune regulation, laying a foundation for improving the long-term survival of recipients. The rational application of extended criteria donor lungs and the popularization of ex vivo lung perfusion technology have enhanced the utilization efficiency and safety of marginal donor lungs. Refined assessment of risk factors such as donors’ smoking history and infectious status has reduced the incidence of primary graft dysfunction and postoperative infection. In terms of recipient management, individualized assessment systems have been gradually optimized. The standardized application of intraoperative extracorporeal membrane oxygenation and the development of minimally invasive surgical techniques have effectively alleviated perioperative injuries. The optimization of postoperative immunosuppressive regimens and advances in rejection monitoring technologies have further improved the long-term survival of grafts. Nevertheless, chronic graft dysfunction and recurrent or refractory infections remain the major bottlenecks restricting long-term prognosis. Future research should focus on expanding donor sources, improving the repair quality of marginal donor lungs, promoting precise immunosuppression and anti-infection strategies, and comprehensively enhancing the long-term survival rate and quality of life of lung transplant recipients.
