Clinical application of dual-donor liver transplantation
10.12464/j.issn.1674-7445.2026040
- VernacularTitle:双供者肝移植技术的临床应用
- Author:
Mingqiang ZHU
1
;
Jiufei YANG
1
;
Qicheng LIAO
1
;
Zhenfu OUYANG
2
;
Xiaohua WANG
1
;
Xiao HE
1
;
Youming DING
2
;
Xing XIE
1
Author Information
1. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
2. null.
- Publication Type:ReviewArticle
- Keywords:
Dual-donor;
Liver transplantation;
Donor liver shortage;
Donor evaluation;
Living organ donation;
Donation after citizen’s death;
Small-for-size syndrome;
Graft atrophy
- From:
Organ Transplantation
2026;17(5):859-866
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is a radical treatment for progressive and irreversible end-stage liver disease. However, its clinical application has always been restricted by the core bottleneck of donor liver shortage. Living donor liver transplantation can alleviate the shortage of donor livers to a certain extent, but it requires simultaneous assurance of sufficient residual liver volume in donors to avoid liver insufficiency, as well as an adequate graft-to-recipient weight ratio to prevent small-for-size syndrome, which limits its clinical application. Dual-donor liver transplantation utilizes partial liver tissues from two donors as grafts. While ensuring donor safety, avoiding small-for-size syndrome in recipients, and expanding the donor pool, this technique significantly improves the utilization rate of donor livers and effectively eases the clinical contradiction of donor liver shortage. Based on recent domestic and international clinical practices and the latest diagnosis and treatment guidelines, this article systematically reviews the developmental background, donor and recipient evaluation and selection, surgical procedures and postoperative complications of dual-donor liver transplantation, aiming to provide references for the standardized promotion and clinical optimization of this technique.
