Research progress on chemical constituents and pharmacological effects of hemp seed oil
- VernacularTitle:火麻仁油化学成分及药理作用的研究进展
- Author:
Sinan WU
1
;
Yaqian WANG
1
;
Yang LIU
1
;
Jincan XIE
2
;
Mengxiao JIA
1
;
Xiali ZHU
1
Author Information
1. School of Pharmacy，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Materia Medica College，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
chemical constituents;
pharmacological effects;
anti-oxidation;
anti-inflammation;
intestinal microbiota
- From:
China Pharmacy
2026;37(17):2344-2348
- CountryChina
- Language:Chinese
-
Abstract:
Hemp seed oil serves as the core pharmacodynamic part of hemp seed， containing various active constituents including fatty acids and their esters （such as linoleic acid， methyl linolenate， etc.）， tocopherols （such as α -tocopherol， β -tocopherol， etc.）， polyphenols （such as caffeic acid， quercetin， etc.）， and cannabinoids （such as cannabidiolic acid， cannabinol， etc.）. Pharmacological studies demonstrate that hemp seed oil exerts anti-oxidation and anti-aging， blood-lipid-lowering and anti-atherosclerotic， neuroprotective， anti-inflammatory effects， as well as functions in regulating intestinal microecology and improving intestinal mucosal barrier function. Its mechanisms are related to scavenging free radicals， activating endogenous antioxidant enzymes， improving the function of central cholinergic system， mitigating neuroinflammatory responses， regulating the balance of inflammatory factors， interfering with inflammatory signaling pathways， and optimizing the structure of intestinal microbiota. In future studies， a correlation network of “chemical component group-multi-target pharmacodynamic effect” can be constructed according to the chemical characteristics of hemp seed oil， and its pharmacodynamic evaluation for chronic diseases can be expanded， so as to promote its in-depth development and clinical transformation.
