Research progress in novel drug delivery systems of breviscapine
- VernacularTitle:灯盏花素新型给药系统的研究进展
- Author:
Yuchuan CHENG
1
;
Weize LI
2
;
Ning LI
1
;
Yuanyuan LI
1
;
Ruixia KANG
1
;
Dan WU
1
Author Information
1. Institute of Chinese Materia Medica Formula，Shanxi Academy of Traditional Chinese Medicine，Taiyuan 030012，China
2. School of Pharmacy，Xi’an Medical University，Xi’an 710021，China
- Publication Type:Journal Article
- Keywords:
solubility;
permeability;
bioavailability;
novel drug delivery systems
- From:
China Pharmacy
2026;37(17):2338-2343
- CountryChina
- Language:Chinese
-
Abstract:
Breviscapine （Bre）， the effective flavonoid fraction extracted from Erigeron breviscapus ， contains more than 90% scutellarin. It exerts pharmacological effects including cardiovascular protection， neuroprotection， anti-tumor activity and immunomodulation. Nevertheless， Bre has several drawbacks such as low solubility， low permeability， poor stability and short half-life， which greatly restrict its clinical application. Novel drug delivery systems （NDDS） are carriers that integrate multi-dimensional technologies including solubilization， penetration enhancement， sustained/controlled release and targeted delivery to achieve efficient drug delivery. This paper systematically summarizes the research progress of Bre-NDDS， which mainly covers oral preparations （sustained/controlled-release drug delivery systems， immediate-release drug delivery systems）， injectable preparations （liposomes， solid lipid nanoparticles， lipid emulsions， polymeric nanoparticles， polymeric micelles）， mucosal delivery systems （nasal mucosal drug delivery systems， buccal mucosal drug delivery systems， pulmonary mucosal drug delivery systems） and transdermal delivery systems. The preparation routes as well as in vitro and in vivo performances of various Bre-NDDS are analyzed. The design principles for NDDS based on pharmacokinetics/pharmacodynamics are put forward， which can provide scientific evidence for the research， development and industrialization of high-efficiency and safe new Bre preparations.
