Preoperative nebulized indocyanine green-assisted thoracoscopic anatomical lesion resection for congenital pulmonary airway malformations in children: A retrospective cohort study
- VernacularTitle:术前雾化吸入吲哚菁绿辅助胸腔镜下解剖性病灶切除术治疗小儿先天性肺气道畸形的回顾性队列研究
- Author:
Hongguang SHI
1
;
Junpeng DU
1
;
Jiaxi WANG
1
;
Peiliang SUN
1
;
Zhenqiu CHEN
1
;
Weibo ZHANG
1
;
Zhe FU
1
;
Mingjun ZHENG
1
;
Yongqian MA
1
Author Information
1. Department of Pediatric Surgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, P. R. China
- Publication Type:Journal Article
- Keywords:
Thoracoscopy;
congenital pulmonary airway malformation;
indocyanine green;
anatomical lesion resection;
nebulized inhalation;
child
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(09):1412-1418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of preoperative nebulized indocyanine green (ICG)-assisted thoracoscopic anatomical lesion resection (TALR) in treating pediatric congenital pulmonary airway malformation (CPAM). Methods A retrospective analysis was conducted on clinical data of 45 children with CPAM who underwent thoracoscopic surgery at the Third Affiliated Hospital of Zhengzhou University between June 2023 and March 2025. The patients were divided into an ICG group (preoperative nebulized ICG 0.5 mg/kg+TALR) and a non-ICG group (TALR under white light), with perioperative and postoperative recovery parameters compared between groups. Results A total of 45 children [22 males, 23 females; median age 7.4 (1.1-75.0) months] were enrolled. The ICG group (n=22) and non-ICG group (n=23) both achieved uneventful recoveries. Compared to the non-ICG group, the ICG group demonstrated significantly shorter surgical duration [91.3 (38.0-144.0) min vs. 100.0 (50.0-175.0) min, P=0.032], reduced intraoperative blood loss [3.0 (2.0-10.0) mL vs. 5.0 (1.0-10.0) mL, P=0.049], shorter postoperative drainage duration [2.7 (1.9-3.9) d vs. 3.4 (1.8-19.9) d, P=0.003], and shortened hospital stay [4.6 (2.9-9.8) d vs. 5.0 (3.9-21.5) d, P=0.013]. Residual lesions occurred in 2 patients from the non-ICG group but none in the ICG group. Intragroup comparisons revealed significant improvements in ratio of time to peak tidal expiratory flow to expiratory time, ratio of volume to peak tidal expiratory flow to expiratory volume, and tidal volume per kilogram after surgery in both groups (P<0.05), though intergroup differences showed no statistical significance (P>0.05). Conclusion Preoperative nebulized ICG administration facilitates lesion identification in CPAM, reduces technical difficulty of TALR, enhances therapeutic outcomes, and provides valuable assistance for performing TALR procedures.
