Mendelian randomization study of sleep duration and sleep disorders in relation to age at menarche in females
10.16835/j.cnki.1000-9817.2026216
- VernacularTitle:睡眠时长和睡眠障碍与女性月经初潮年龄的孟德尔随机化研究
- Author:
YUAN Jiajun, ZHANG Ye, CHEN Tingjun, REN Yaping, NING Zidi, LU Ruoyu, 〖JZ〗WANG Xiaoman, ZHAO Anda, LI Jinzhe, WANG Zeyu, HU Hui, SUN Ying，BAI Pinqing, LI Shenghui
1
Author Information
1. Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP)/Shanghai Children s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
- Publication Type:Journal Article
- Keywords:
Sleep;
Sleep disorders;
Menarche;
Growth and development;
Female
- From:
Chinese Journal of School Health
2026;47(7):1021-1025
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the potential genetic causal relationship between sleep related phenotypes and female pubertal onset using the two sample Mendelian randomization approach.
Methods:Genetic instrumental variables for sleep and age at menarche were sourced from FinnGen, IEU Open GWAS and GWAS Catalog three publicly available Genome Wide Association Study databases. Causal effects were estimated using the inverse variance weighted method, supplemented by sensitivity analyses and tests for heterogeneity, pleiotropy, and direction.
Results:Genetically predicted sleep duration was positively associated with age at menarche ( β =0.61, 95% CI =0.30-0.91, P <0.01). Conversely, overall sleep problems ( β =-0.13, 95% CI =-0.20 to -0.07 ), two specific types of sleep disorders (sleep apnea: β =-0.10, 95% CI =-0.16 to -0.03; insomnia: β =-0.40, 95% CI = -0.69 to -0.11) were causally associated with earlier age at menarche (all P <0.01). Sensitivity analyses confirmed the robustness of these findings with consistent effect directions and no evidence of significant directional pleiotropy.
Conclusions:The study reveales a genetic causal relationship between sleep and pubertal onset. Adequate sleep duration appears to have a protective effect. These findings suggest that sleep may have a critical regulatory role in the initiation of pubertal development.
