Research progress on bacterial extracellular vesicles in dental caries and periodontal disease
10.12016/j.issn.2096-1456.202550516
- Author:
CHEN Jiaqi
1
;
YANG Jiaojiao
2
;
LI Jiyao
1
Author Information
1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
2. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases
- Publication Type:Review
- Keywords:
bacterial extracellular vesicles;
Streptococcus mutans;
Porphyromonas gingivalis;
Fusobacterium nucleatum;
dental caries;
periodontal disease;
oral-systemic axis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2026;34(9):895-905
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial extracellular vesicles (BEVs) are nanoscale, lipid bilayer-enclosed vesicles that are actively or passively released by bacteria. They carry diverse bioactive cargos, including proteins, nucleic acids, and lipids, and mediate information exchange between microbial communities and hosts. Increasing evidence indicates that BEVs play important roles in the initiation and progression of dental caries and periodontitis. In dental caries, BEVs derived from cariogenic bacteria such as Streptococcus mutans can promote biofilm formation and maturation, enhance the acidic microenvironment, and exacerbate demineralization of dental hard tissues. In periodontitis, BEVs released by key periodontal pathogens, including Porphyromonas gingivalis and Fusobacterium nucleatum, may disrupt the mucosal barrier, trigger inflammatory responses, and activate bone resorption-related pathways, thereby promoting periodontal tissue destruction. Owing to their detectability, BEVs in oral samples such as saliva, dental plaque, and gingival crevicular fluid show promise as diagnostic biomarkers and also provide new therapeutic opportunities for targeted interventions. In addition, emerging studies suggest that oral BEVs may contribute to distal inflammatory amplification through an “oral-systemic axis”; therefore, while focusing on the local pathogenic mechanisms of BEVs in dental caries and periodontitis, this review also briefly outlines their potential systemic implications as an extension. Overall, BEVs may offer novel mechanistic insights and translational directions to support precise prevention and management of dental caries and periodontitis.
- Full text:2026091115285598530细菌胞外囊泡在龋病和牙周病中的研究进展.pdf
