Selective lymphadenectomy, based on prior lymphatic mapping and sentinel node identification and excision, is now the standard management for intermediate thickness melanomas in many cancer centers worldwide. In our country and our institution in particular, we have very limited experience on lymphatic mapping and sentinel node biopsy for cutaneous melanoma due to the relative rarity of this lesion and also due to the prohibitive cost of the procedure and availability of equipments. These factors , however, should not be made as an excuse for us not to have an understanding of the usefulness of the procedure as well as the drawbacks in the technique. Thus, we would like to report on our experience with lymphatic mapping and sentinel node biopsy using unfiltered technetium sulfur colloid and vital blue dye in a patient with intermediate thickness melanoma and perform a review of the literature regarding the clinical significance of the sentinel node localization procedure in the management of cutaneous melanoma.