Chemical Components and Pharmacological Effects of Lianpo Yin： A Review of Ancient and Modern Literature
10.13422/j.cnki.syfjx.20260295
- VernacularTitle:连朴饮化学成分、药理作用及古今文献研究进展
- Author:
Zhen CHEN
1
;
Wenzhao LUO
2
;
Yu ZHAO
1
;
Mengdie WU
1
;
Qian CHEN
2
;
Xian LI
2
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450053，China
2. The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
Lianpo Yin;
chemical components;
pharmacological effects;
ancient and modern literature;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(19):335-346
- CountryChina
- Language:Chinese
-
Abstract:
Lianpo Yin was first recorded in the Revised Treatise on Cholera from Suixi Residence by WANG Mengying. It is composed of seven medicinal herbs： Coptidis Rhizoma， Magnoliae Officinalis Cortex， Sojae Semen Praeparatum， Acori Tatarinowii Rhizoma， Pinelliae Rhizoma， Gardeniae Fructus， and Phragmitis Rhizoma. As one of the classic prescriptions for clearing heat， resolving dampness， regulating Qi， and harmonizing the middle energizer， it has been included in the Catalogue of Ancient Classic Prescriptions （Second Batch： Han Chinese Medicine） published by the National Administration of Traditional Chinese Medicine in 2023. Lianpo Yin is primarily indicated for cholera caused by the accumulation of dampness-heat， and it can promote digestion and eliminate phlegm. By summarizing the ancient literature records， chemical constituents of individual herbs and the compound formula， pharmacological effects， and modern clinical applications of Lianpo Yin， this paper discovers that the understandings of most ancient physicians are consistent with the original text. The pathogenesis treated by this prescription is generally attributed to the accumulation of dampness-heat in the middle energizer and disrupted ascending and descending of Qi. The main chemical components of this prescription include coptisine， trigonelline， genistein， palmatine， berberine， honokiol， and magnolol. Lianpo Yin exhibits pharmacological effects such as anti-inflammatory activity， regulation of apoptosis， modulation of mitochondrial autophagy， regulation of the hypothalamic-pituitary-adrenal （HPA） axis， promotion of gastrointestinal motility， improvement of the gastric mucosal barrier， regulation of intestinal flora and their metabolites， and antimicrobial activity. In modern clinical practice， this prescription is mainly used to treat digestive system diseases such as chronic superficial gastritis and Helicobacter pylori （Hp）-associated gastritis. Additionally， it demonstrates significant therapeutic effects on various diseases affecting the nervous， respiratory， dermatological， and cardiovascular systems. This study provides a detailed review of the ancient literature records， chemical components， pharmacological effects， and clinical applications of Lianpo Yin and its modified formulas， aiming to offer references for the dosage form development and broader clinical application of this classic prescription.
