Research Progress on Pathogenesis and Targeted Intervention Strategies of Chinese Herbal Active Components in Autism Spectrum Disorder： A Review
10.13422/j.cnki.syfjx.20250811
- VernacularTitle:中药活性成分靶向干预孤独症研究进展
- Author:
Lyuyuan LIANG
1
;
Jialei CAO
1
;
Shengjia DING
1
;
Qirong WANG
1
;
Yiping WANG
1
;
Fangyuan CHEN
1
;
Fengzhen GUO
1
;
Yunkai WANG
2
;
Yuxin ZHANG
3
;
Yuxin LI
1
;
Bingqi WEI
4
;
Bingxiang MA
1
;
Weili DANG
1
Author Information
1. Pediatric Hospital， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450099，China
2. School of Chinese Medicine， Macau University of Science and Technology， Macao 999078，China
3. Pediatric Medical College， Henan University of Chinese Medicine， Zhengzhou 450046，China
4. Henan Provincial Hospital of Chinese Medicine，The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
autism;
active components of Chinese herbal medicine;
oxidative stress;
ferroptosis;
synapse;
baicalin
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(19):303-314
- CountryChina
- Language:Chinese
-
Abstract:
Autism Spectrum Disorder （ASD） is a neurodevelopmental disorder with rapidly increasing global prevalence， characterized by core symptoms of social communication deficits and stereotyped repetitive behaviors. Although genetic predisposition， abnormal epigenetic regulation， perinatal environmental exposure， and nutritional-metabolic imbalances are recognized as major risk factors， the precise etiological mechanisms remain incompletely understood. Current clinical management primarily relies on behavioral interventions， with limited pharmacological options accompanied by adverse effects. Recent studies have demonstrated the unique therapeutic value of active components from Chinese herbal medicine in ASD intervention. This article reviews the mechanisms underlying various Chinese herbal active components in ASD treatment， including improvements in synaptic dysfunction， blood-brain barrier impairment， neurotransmitter regulation， cerebellar dysfunction， immune dysregulation and neuroinflammation， oxidative stress， programmed neuronal cell death， and lipid metabolism. These bioactive components exhibit multi-target and multi-pathway regulatory effects， providing novel therapeutic strategies and directions for ASD.
