Prevention and Treatment Strategies for Chronic Atrophic Gastritis Based on Theory of Vigorous Fire Consuming Qi and ROS/NLRP3-mediated Inflammation-mitochondrial Damage Axis
10.13422/j.cnki.syfjx.20251213
- VernacularTitle:基于“壮火食气”理论与ROS/NLRP3介导的“炎症-线粒体损伤”探讨慢性萎缩性胃炎的防治思路
- Author:
Yu SHEN
1
;
Shijin LIN
1
;
Sihan LI
2
;
Minghan HUANG
1
;
Jingyao SHI
3
;
Zeyu ZHENG
1
;
Chunbo YANG
1
;
Youcheng HE
1
Author Information
1. The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine （TCM）， Fuzhou 350003， China
2. West China Hospital， Sichuan University， Chengdu 610041， China
3. People's Hospital Affiliated to Fujian University of TCM， Fuzhou 350004， China
- Publication Type:Journal Article
- Keywords:
chronic atrophic gastritis;
vigorous fire consuming Qi;
inflammation;
mitochondria damage;
reactive oxygen species （ROS）/NOD-like receptor protein 3 （NLRP3）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(19):287-295
- CountryChina
- Language:Chinese
-
Abstract:
Chronic atrophic gastritis （CAG）， a premalignant gastric condition， represents a critical stage in inflammation-cancer transformation. In this pathological process， mitochondrial damage serves as a key mediator in the inflammation-driven transformation of normal gastric mucosal epithelial cells into gastric cancer cells， while the dysregulation of the reactive oxygen species （ROS）/NOD-like receptor protein 3 （NLRP3） axis plays a key role in perpetuating the vicious cycle of inflammation-mitochondrial damage. The classical theory of traditional Chinese medicine （TCM）， vigorous fire consuming Qi， aptly encapsulates this pathological feature. The essence of this theory lies in the struggle between pathogenic and vital factors， wherein vigorous fire shares similarities with chronic inflammation and may be regarded as a driving force behind inflammation-cancer transformation. Qi reflects the mitochondrial function， and consuming Qi signifies structural and functional impairment of mitochondria. Thus， this theory accurately summarizes the pathological characteristics of inflammation-mitochondrial damage during CAG progression. Building upon this theoretical framework， the theory of vigorous fire consuming Qi provides a holistic understanding of CAG pathogenesis. Reviewing the clinical expertise of TCM master YANG Chunbo in treating spleen-stomach disorders， this paper further elucidates its therapeutic implications： modulating systemic inflammatory responses to restore gastric mucosal homeostasis and targeting mitochondrial damage as a pivotal intervention to delay CAG progression. Clinically， achieving dynamic equilibrium between fire and Qi is essential， mitigating excessive inflammation without compromising vital Qi， while reinforcing Qi without exacerbating pathological fire. This approach offers novel insights for developing preventive and therapeutic strategies against CAG.
