Material Basis， Pharmacological Mechanisms， and Quality Control of Antitumor Effect of Cremastrae Pseudobulbus Pleiones Pseudobulbus： A Review
10.13422/j.cnki.syfjx.20260964
- VernacularTitle:山慈菇抗肿瘤的物质基础、药理机制及质量控制研究进展
- Author:
Yuanye GU
1
;
Ruonan QIANG
2
;
Zheyu XU
2
;
Ruyun CAO
1
;
Qiye PAN
1
;
Zhenyu YANG
1
;
Tian XIA
3
;
Qingyuan CHI
3
;
Haojing WANG
1
;
Xian GU
1
Author Information
1. Longhua Hospital，Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China
2. Dongzhimen Hospital，Beijing University of Chinese Medicine，Beijing 100700，China
3. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China
- Publication Type:Journal Article
- Keywords:
Cremastrae Pseudobulbus Pleiones Pseudobulbus;
antitumor effect;
material basis;
pharmacological mechanism;
quality control;
quality marker
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(19):258-268
- CountryChina
- Language:Chinese
-
Abstract:
Cremastrae Pseudobulbus Pleiones Pseudobulbus is a Chinese medicinal material used for clearing heat， detoxicifying， resolving phlegm， and dissipating nodules. It is derived from Cremastra appendiculata， Pleione bulbocodioides， or Pleione yunnanensis， as recorded in the 2025 edition of the Pharmacopoeia of the People′s Republic of China， with the former known as Maocigu and the latter two known as Bingqiuzi. Current antitumor studies mainly focus on polysaccharides， water-extracted alcohol-precipitated fractions， and purified extracts of C. appendiculata. Structurally characterized glucomannans suppress breast and liver tumor xenografts and exhibit immunomodulatory effects. The water-extracted alcohol-precipitated fractions inhibit tumor angiogenesis in hepatoma-bearing mice. A purified C. appendiculata extract standardized to five phenanthrene and bibenzyl constituents induces mitochondrial apoptosis in hepatocellular carcinoma cells. Reported pharmacological effects involve cell-cycle regulation， apoptosis， epithelial-mesenchymal transition， angiogenesis， autophagy， and the tumor immune microenvironment， with phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin （PI3K/Akt/mTOR）， Wnt/β-catenin， and Janus kinase 2/signal transducer and activator of transcription 3 （JAK2/STAT3） signaling pathways being the major mechanism links. Quality evaluation of Cremastrae Pseudobulbus Pleiones Pseudobulbus has progressed from single-marker assays to an integrated approach involving botanical authentication， chromatographic fingerprinting， multicomponent analysis， and evaluation of associations between blood-absorbed constituents and antitumor effects. Militarine and dactylorhin A can be used for botanical identification and batch evaluation， and in vivo exposure data from related orchids are concentrated on militarine. Quantitative associations between these constituents and antitumor effects remain to be established. Clinical evidence mainly focuses on formula-based applications and expert experience. Comparative antitumor data in hepatoma models are available for the commercial specifications of Maocigu and Bingqiuzi， whereas parallel evaluations of pharmacological effects， safety windows， and drug interactions among the three official botanical origins remain insufficient. The major limitations are the incomplete standardization of botanical origins and preparations and the lack of quantitative links among quality markers， systemic exposure， antitumor effects， and toxicity endpoints， which constrain reproducible pharmacological evaluation and clinical translation of Cremastrae Pseudobulbus/Pleiones Pseudobulbus.
