From Spleen Deficiency with Dampness Excess to Stasis-toxin Damaging Collaterals： Dynamic Management Path in Whole-course Treatment Strategies for Ulcerative Colitis
10.13422/j.cnki.syfjx.20260592
- VernacularTitle:从“脾虚湿盛”到“瘀毒蚀络”： 溃疡性结肠炎全程治疗策略的动态管理路径
- Author:
Zhili ZHENG
1
;
Hongzheng LI
1
;
Shaoli WANG
2
;
Tiantong JIANG
2
;
Yuan DING
2
;
Qiongqiong LU
3
;
Zhen LIU
2
Author Information
1. Postdoctoral Department，China Academy of Chinese Medical Sciences，Beijing 100700，China
2. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China
3. Chongqing Traditional Chinese Medicine Hospital，Chongqing 400021， China
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
spleen deficiency with dampness excess;
stasis-toxin damaging collaterals;
dynamic pathogenesis cascade;
whole-course management
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(19):147-153
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC）， a chronic nonspecific inflammatory bowel disease characterized by unclear etiology， complex contributing factors， and a refractory course with malignant transformation potential， imposes a substantial burden on both individual patients and healthcare systems. There is an urgent need to explore effective therapeutic strategies and pharmacological interventions. Professor LIU Zhen， based on years of clinical practice， proposed a dynamic pathogenesis chain of UC： Spleen deficiency with dampness excess as the foundation， dampness obstruction as the nexus， stasis-toxin interaction as the key， and stasis-toxin damaging intestinal collaterals as the terminal outcome. The treatment， following the progression of deficiency （depression）-dampness-toxin-stasis （toxin）， should focus on invigorating the spleen and resolving dampness. A stage-specific treatment approach is emphasized. During the susceptible stage， prevention is recommended， which relies on regulating the diet， maintaining a positive mental state， and adjusting daily routines to invigorate the spleen and replenish Qi. During the acute attack and remission stages， the treatment should be tailored according to clinical typing and disease severity， flexibly employing therapeutic strategies such as tonifying deficiency， resolving depression， eliminating dampness， clearing heat， detoxifying， arresting bleeding， and resolving stasis in order to interrupt disease progression. In the recovery stage， latent pathogenic factors should be addressed while the postnatal constitutional foundation be preserved to prevent recurrence. According to the TCM principle of treating disease before its onset， a whole-course management path of early protection-interception-stratified care-consolidation has been developed， covering all stages of UC， to inform its clinical prevention and treatment.
