Objectives: This paper aimed to describe the characteristics of patients with clinically localized prostate cancer who underwent radical prostatectomy according to age, transrectal ultrasound-guided biopsy (TRUS) Gleason's score, histopathologic Gleason's score, histopathologic tumor stage, number of transfusions, complications and type of anesthesia used. It further aimed to compare the no. of complications by mean age, PS A levels, TRUS prostate volume, operating time, blood loss and hospital stay among patients with and without complications. Finally, it aimed to determine significant association of TRUS biopsy Gleason's score, histopathologic Gleason's score , histopathologic tumor stage, number of transfusions, and type of anesthesia used with the development of complications. Methods: This is a retrospective cohort study done by examining hospital records of patients with clinically localized prostate cancer (stage 2c and below), who underwent radical prostatectomy from 1996-2005 at UST Hospital, done by a single surgeon. Data were analyzed with SPSS v.ll, using Cramer's V statistic at the 0.05 level of significance. Results/Conclusion: A total of 41 subjects were included in the study. Subjects had a mean age of 65.85 years, with mean PSA levels of 16.22 ng/dL and TRUS volume of 35.64ml. All subjects had Gleason's Biopsy scores of 4 and above, with majority having scores between 4-6 (78.04 percent). Histopathologic results showed that 82.9 percent of the subjects had scores between 4 to 6. The majority of subjects had tumor stage of T2c (75.6 percent). Thirty-two of 41 cases (78 percent) did not require blood transfusions and only 17 percent (7/41) had post-operative complications, in the form of bladder neck contractures, clot retention, iatrogenic external iliac vein lacerations, postoperative ileus and incontinence. Majority (40/41) required only epidural anesthesia. The mean operating time was 3.65 hours with blood loss of 847.56 ml. Average hospital stay was 5.29 days. TRUS biopsy Gleason's score, histopathologic Gleason's score, histopathologic tumor stage, type of anesthesia and blood transfusions were not significantly associated with development of postoperative complications. (Author)