Research progress on the relationship between gut microbiota, their metabolites, and aortic diseases
- VernacularTitle:肠道微生物及其代谢物与主动脉疾病关系的研究进展
- Author:
Xiaokang LUO
1
;
Dantong SHAO
2
;
Tucheng SUN
1
;
Xinjian YAN
1
,
3
Author Information
1. Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China
2. Department of Women's Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, P. R. China
3. Xinjiang Key Laboratory of Artificial Intelligence Assisted Imaging Diagnosis, Kashi, 844099, Xinjiang, P. R. China
- Publication Type:Journal Article
- Keywords:
Aortic disease;
aortic aneurysm;
aortic dissection;
gut microbiome;
gut dysbiosis;
microbial metabolites
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(08):1330-1336
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of aortic disease is not fully understood. Gut dysbiosis may play a role in the occurrence and development of aortic diseases. Several studies showed that the diversity of microbiota in abdominal aortic aneurysms significantly decreases and is correlated with the diameter of the aneurysm. Characteristic microbial communities associated with abdominal aortic aneurysm, such as Roseburia, Bifidobacterium, Ruminococcus, Akkermansia have been found in human and animal studies. The gut microbiota of patients with aortic dissection varies greatly. Characteristic microbial communities like Lachnospiraceae and Ruminococcus present a potential impact on the pathogenesis of aortic dissection. Bifidobacteriaceae may be associated with Takayasu arteritis and thoracic aortic aneurysm. The gut microbiota affects the physiological functions of the host by synthesizing bioactive metabolites, which causes aortic diseases, mainly involving metabolites such as trimethylamine N-oxide, lipopolysaccharides, tryptophan, and short chain fatty acids. More and more evidence supports the causal relationship between gut microbiota dysbiosis and aortic disease. Clarifying abnormal changes in gut microbiota may provide clues for finding potential therapeutic targets.
