Current status and associated factors of human rabies immunoglobulin use in children with rabies exposure
- VernacularTitle:狂犬病暴露患儿狂犬病人免疫球蛋白的使用现状及相关因素分析
- Author:
Jinxiang LIN
1
;
Li CHEN
1
;
Huichao KE
2
;
Suping LI
1
;
Yushuang CHEN
1
;
Qingchi ZHANG
3
Author Information
1. Dept.of Pharmacy，Xiamen Children’s Hospital（Children’s Hospital of Fudan University at Xiamen），Fujian Xiamen 361006，China
2. Dept. of Emergency，Xiamen Children’s Hospital（Children’s Hospital of Fudan University at Xiamen），Fujian Xiamen 361006，China
3. Dept.of General Surgery，Xiamen Children’s Hospital（Children’s Hospital of Fudan University at Xiamen），Fujian Xiamen 361006，China
- Publication Type:Journal Article
- Keywords:
human rabies immunoglobulin;
rabies;
passive immunization;
Children;
head and face exposure;
Influencing factors
- From:
China Pharmacy
2026;37(16):2176-2180
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the current status and associated factors of human rabies immunoglobulin （HRIG） use in children with rabies-exposure， so as to provide a reference for the rational use of HRIG.METHODS Clinical data of children with rabies-exposure who were admitted to the outpatient and emergency departments of Xiamen Children’s Hospital from January to December 2024 were retrospectively collected. HRIG use in these children was analyzed， and univariate and multivariate Logistic regression analyses was used to identify independent risk factors for non-use of HRIG among children indicated for it.A questionnaire survey was conducted to assess 42 surgeons’ knowledge of rabies-post-exposure prophylaxis，self-rated factors influencing HRIG use，and reasons for non-use in high-risk exposure scenarios.RESULTS A total of 564 pediatric patients were enrolled， of whom 122 met the indications for HRIG use； however， only 24 received HRIG， yielding an actual utilization rate of 19.67%. Multivariate Logistic regression analysis showed that head and facial exposure was an independent risk factor for non-use of HRIG [OR＝7.77， 95%CI （1.11， 54.27）， P ＝0.039]. The questionnaire survey revealed that surgeons had the lowest awareness rate regarding the time to antibody production after rabies vaccination （35.71%）， followed by the appropriate timing of HRIG administration （50.00%）. Among the self-rated factors influencing HRIG use by surgeons， wound depth and bleeding status had the highest mean scores （2.95 points）. The primary reasons for non-use HRIG in special cases and grade Ⅲ exposure pediatric patients were the judgment that the offending animal was healthy or posed low risk，accounting for 45.24% and 38.10%， respectively； followed by parental refusal due to cost， pain， or other concerns，accounting for 26.19% and 33.33%， respectively.CONCLUSIONS The actual utilization rate of HRIG among children meeting the indications for HRIG use in our hospital was relatively low. Head and facial exposure was an independent risk factor for non-use of HRIG. Some surgeons had insufficient understanding of the time to antibody production after rabies vaccination and the appropriate timing of HRIG administration. Animal-related risk assessment and parental preferences may influence the use of HRIG.
