Analysis of the efficiency of HLA-compatible platelet matching using a platelet genotype database
10.13303/j.cjbt.issn.1004-549x.2026.08.016
- VernacularTitle:血小板基因数据库HLA相容性配合效率的分析
- Author:
Jiangtian CHEN
1
;
Xianguo XU
1
;
Xiaozhen HONG
1
;
Kairong MA
1
;
Junfeng GUO
1
;
Wei ZHANG
1
;
Faming ZHU
1
Author Information
1. Blood Center of Zhejiang Province, Hangzhou 310052, China
- Publication Type:Journal Article
- Keywords:
platelet genotype matching;
operational efficiency;
matching strategy;
platelet gene database
- From:
Chinese Journal of Blood Transfusion
2026;39(8):1105-1109
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the operational efficiency of a single-center platelet genotype database in HLA genotype-matched platelet search and applcation, and to compare the efficiency among different matching strategies, hospitals, and between first-time versus repeat application modes. Methods: Data on platelet genotype-based matching applications from December 1, 2025, to May 31, 2026, at our center were collected. Four time intervals were defined according to the workflow: the time from clinical hospital application to blood center receipt confirmation (Δt
); the time from blood center confirmation to completion of platelet gene database search (Δt
); the time from completion of database searching to availability of compatible platelet products (Δt
); and the time from clinical hospital application to availability of compatible platelet products (Δt
). Applications were classified as first-time or repeat based on application history, and as speed-priority matching strategy or classical matching strategy based on matching approach, with efficiency differences compared across the groups. Results: A total of 1 051 valid matching applications were included. The median values of Δt
, Δt
, Δt
, and Δt
were 6.2 h, 0.1 h, 0.2 h, and 11.5 h, respectively. Overall, 55.9% of genotype-based matches resulted in compatible platelets being available on the same day. The median Δt
of the speed-priority strategy was significantly shorter than that of the classical strategy (5.2 h vs 39.6 h, P<0.001). Median Δt
differed significantly among hospitals (P<0.001), with the shortest being 4.4 h. The median Δt
for repeat applications was 6.9 h, significantly shorter than that for first-time applications (27.7 h, P<0.001). Conclusion: The platelet gene database demonstrates sufficient efficiency in HLA genotype-matched platelet searching and application to meet clinical demands. Optimizing matching strategies and hospital application workflows may shorten the time for obtaining compatible platelets.
