Research progress on biosynthesis, content determination and biological activity of volatile oil components in Perillae folium
10.12206/j.issn.2097-2024.202412058
- VernacularTitle:紫苏叶挥发油成分的生物合成、含量测定及生物活性研究进展
- Author:
Huiping LI
1
;
Lu CHEN
2
;
Qijin ZHANG
3
;
Baokang HUANG
1
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. Department of Pharmacy,Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital,Shanghai 201318,China.
3. School of Pharmacy, Naval Medical University, Shanghai 200433, China;Department of Clinical Pharmacy, Western Theater General Hospital, Chengdu 610036, China.
- Publication Type:Reviews
- Keywords:
Perillae folium;
volatile oil;
biosynthesis;
content determination;
biological activity
- From:
Journal of Pharmaceutical Practice and Service
2026;44(8):395-399
- CountryChina
- Language:Chinese
-
Abstract:
Perilla leaf volatile oil is rich in monoterpenes, aromatic compounds, and other active constituents, with perillaldehyde as its characteristic marker, exhibiting a wide range of pharmacological activities including antibacterial, anti-inflammatory, and antitumor effects. In recent years, systematic studies have been conducted on its chemical composition and pharmacodynamic basis. The methods for content determination have become increasingly sophisticated, with gas chromatography-mass spectrometry (GC-MS) and other techniques being widely applied for comparative analysis of samples from different sources; however, the results are influenced by multiple factors such as germplasm variation, growth stage, and extraction process. Regarding the biosynthetic pathway, key enzyme genes involved in the mevalonate and shikimate pathways are being progressively elucidated. In terms of bioactivity, in vivo and in vitro experiments have confirmed that its volatile oil components exert synergistic effects through multi-target mechanisms, with applications extended to food preservation, flavor and fragrance industry, and pharmaceutical field. The research progress on the biosynthesis, content determination, and bioactivities of volatile oil components from perilla leaves was reviewed, aiming to further clarify the active material basis and mechanisms of action, and to provide a reference for more in-depth exploration and utilization of the medicinal and edible value of Perilla frutescens.
