Research on aldehyde dehydrogenase 2 in improving the prognosis of ferroptosis-related diseases
10.12206/j.issn.2097-2024.202411043
- VernacularTitle:醛脱氢酶2改善铁死亡相关疾病预后的研究进展
- Author:
Fengping ZHAO
1
;
Zhenming YU
1
;
Xi CHEN
2
;
Qiwen JIANG
2
;
Canhui ZHENG
2
;
Xin CHEN
3
Author Information
1. School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China;School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
3. School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
- Publication Type:Reviews
- Keywords:
oxidative stress;
reactive oxygen species;
ferroptosis;
aldehyde dehydrogenase 2;
toxic aldehydes
- From:
Journal of Pharmaceutical Practice and Service
2026;44(8):383-388
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress is an important pathophysiological pathway for the development and progression of ferroptosis. Under pathological conditions, the production of a large amount of reactive oxygen species （ROS） exceeds the buffering capacity of the antioxidant defense system, resulting in lipid peroxidation and cell ferroptosis in the state of oxidative stress. Cellular lipid peroxidation can generate toxic aldehydes, which interact with important biological macromolecules and break the normal function of cells. At present, it has been found that aldehyde dehydrogenase 2 （ALDH2） can eliminate these aldehydes and regulate the cycle of toxic aldehydes-ROS-oxidative stress-lipid peroxidation, thereby improving the prognosis of diseases associated with iron death. Ferroptosis and ALDH2 were introduced, and the current researches on ALDH2 were summarized to improve diseases associated with iron death, which can open up new directions for the subsequent research on the treatment of diseases associated with iron death.
