Precise Assessment of Endometrial Receptivity: Microengineered Endometrial Chip Model Combined With The Endometrial Receptivity Scoring System
- VernacularTitle:子宫内膜容受性的精准评估：微工程化子宫内膜芯片模型联合子宫内膜容受性评分系统
- Author:
Xiao-Min LIANG
1
;
Hui-Feng YUE
1
Author Information
- Publication Type:Journal Article
- Keywords: endometrial receptivity; embryo implantation; 3D microfluidics; precision medicine
- From: Progress in Biochemistry and Biophysics 2026;53(8):2235-2241
- CountryChina
- Language:English
- Abstract: The establishment of endometrial receptivity is a critical prerequisite for successful embryo implantation and early pregnancy. However, current clinical methods for assessing receptivity are insufficiently validated, and their reliability is inadequate for guiding precision medicine. Although microfluidic organ-on-a-chip models have emerged as promising in vitro platforms garnering significant academic interest, their practical clinical translation has been hindered by challenges in accurately replicating patient-specific microenvironments and the lack of standardized quantitative evaluation systems. Recently, Lee et al. published a groundbreaking study in Nature Communications, which effectively addresses these critical limitations by integrating a patient-derived vascularized endometrium-on-a-chip (EoC) with a newly developed endometrial receptivity scoring system (ERS2). This commentary offers a comprehensive analysis of the key findings from this work, systematically examining the design, construction, dynamic simulation validation, and translational potential of the EoC-ERS2 platform. This innovative approach successfully transforms conventional subjective assessments of endometrial receptivity into a digitized, objective, and quantitative evaluation framework. As a result, it establishes a robust foundation for a paradigm shift toward personalized infertility management and precision medicine in reproductive health.
