Mechanism of action of adipose tissue-derived extracellular vesicles in liver diseases
- VernacularTitle:脂肪组织来源的细胞外囊泡在肝脏疾病中的作用机制
- Author:
Xiaoyan AO
1
;
Xiaoli FAN
1
;
Leyu ZHOU
1
Author Information
- Publication Type:Review
- Keywords: Extracellular Vesicles; Adipose Tissue; Liver Diseases
- From: Journal of Clinical Hepatology 2026;42(7):1730-1737
- CountryChina
- Language:Chinese
- Abstract: Adipose tissue is a crucial endocrine and immune organ， and its functional dysregulation is closely associated with the development and progression of various liver diseases. In addition to the secretion of classical adipokines， adipose tissue-derived extracellular vesicles （EVs） have emerged as key messengers in its regulation of distal organ function. This review systematically elaborates on the regulatory role of adipose tissue-derived EVs in liver diseases， in which white adipose tissue delivers pathogenic molecules such as miR-103 and CD36 via its EVs and thus drives hepatic insulin resistance， lipid accumulation， and fibrosis， while brown adipose tissue transmits protective signals such as miR-132-3p through its EVs to improve hepatic metabolic homeostasis. This article also summarizes the core mechanisms of action of these EVs and discusses their potential as diagnostic biomarkers and innovative therapeutic strategies.
