Mechanism of action and clinical significance of altered intestinal permeability in liver diseases
- VernacularTitle:肠道通透性改变在肝脏疾病中的作用机制与临床意义
- Author:
Jiasheng DU
1
;
Gang CHEN
1
;
Huan HE
1
;
Xinglong YIN
1
;
Xiaofan YANG
1
Author Information
- Publication Type:Review
- Keywords: Intestinal Permeability; Metabolic Associated Fatty Liver Disease; Alcoholic Liver Disease; Autoimmune Liver Disease; Liver Cirrhosis
- From: Journal of Clinical Hepatology 2026;42(7):1723-1729
- CountryChina
- Language:Chinese
- Abstract: Intestinal permeability plays a pivotal role in the gut-liver axis and has emerged as a critical target for the prevention and treatment of liver diseases. Based on recent studies in China and globally， this article reviews the definitions and interrelationship of intestinal barrier function and intestinal permeability， the methods for assessing intestinal permeability， and the mechanism of action and clinical significance of intestinal permeability in the development and progression of various liver diseases. Studies have shown that increased intestinal permeability is a significant hallmark and an important driving factor for multiple liver diseases， and this state leads to the translocation of bacteria and harmful substances， trigger a systemic inflammatory response， and thus exacerbates liver injury， fibrosis， and metabolic dysregulation. Therefore， it is closely associated with the development and progression of metabolic associated fatty liver disease， alcoholic liver disease， autoimmune liver diseases， and their end-stage events， including liver cirrhosis， liver failure， and hepatocellular carcinoma. Future research should focus on the standardization of assessment methods， the exploration of underlying mechanisms， and the clinical translation of these findings.
