Mechanisms， risks， and management strategies of artificial liver support system in treating liver failure with thrombocytopenia
- VernacularTitle:人工肝支持系统治疗肝衰竭伴血小板减少的机制、风险及管理策略
- Author:
Ru MA
1
;
Zhiwei WANG
1
;
Li MA
1
;
Zihui DING
1
;
Xingyu LI
1
;
Yan WANG
1
Author Information
- Publication Type:Review
- Keywords: Liver Failure; Liver， Artificial; Thrombocytopenia
- From: Journal of Clinical Hepatology 2026;42(7):1717-1722
- CountryChina
- Language:Chinese
- Abstract: Artificial liver support therapy for liver failure is often complicated by thrombocytopenia， which increases the risk of bleeding. This article systematically elaborates on the pathophysiological role of platelets in liver disease， and systematically analyzes the differential effect of various artificial liver support modalities on platelets， with a focus on key factors such as biocompatibility and anticoagulation strategies. This article also summarizes the clinical management approaches including individualized platelet transfusion and the application of thrombopoietic agents and discusses the value of platelet count as a predictive indicator for treatment safety and efficacy， in order to provide a basis for precise clinical intervention.
