Clinical and pathological features of intrahepatic intraductal papillary neoplasm of the bile duct： An analysis of four cases
- VernacularTitle:4例肝内胆管内乳头状肿瘤的临床及病理学特征分析
- Author:
Ying ZHANG
1
;
Qing CAO
1
;
Kaige WANG
1
;
Fan JIA
2
;
Yungang ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Intrahepatic Biliary Papillomatosis; Disease Attributes; Diagnosis
- From: Journal of Clinical Hepatology 2026;42(7):1656-1660
- CountryChina
- Language:Chinese
- Abstract: ObjectiveTo investigate the clinical and pathological features of intrahepatic intraductal papillary neoplasm of the bile duct （IPNB）， and to improve the understanding， diagnosis， and treatment of this disease. MethodsA retrospective analysis was performed for four patients who underwent surgical resection in Beijing Chaoyang Hospital， Capital Medical University， from January 2010 to December 2025 and were diagnosed with intrahepatic IPNB based on pathological examination. The clinical， imaging， and pathological features of these patients were summarized， and a literature review was performed for related articles in China and globally. ResultsAmong the four patients， there were three female patients and one male patient， with a median age of 65 years， and clinical manifestations included jaundice， abdominal pain or diarrhea， and asymptomatic findings on physical examination. The main imaging manifestation was bile duct dilatation or solid-cystic space-occupying lesion. Pathological typing revealed one case each of the gastric， intestinal， pancreatobiliary， and oncocytic types， and there was one patient with low-grade intraepithelial neoplasia and three patients with high-grade intraepithelial neoplasia， among whom one patient also had invasive carcinoma. ConclusionIntrahepatic IPNB is a rare precancerous lesion of the liver with diverse clinical， imaging， and pathological manifestations， and radical surgical resection remains the cornerstone of treatment.
