Research hotspots and advances in contrast-enhanced ultrasound for hepatocellular carcinoma
- VernacularTitle:肝细胞癌超声造影研究热点与进展
- Author:
Wenfei HOU
1
;
Jiajia TANG
1
;
Meng YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Carcinoma， Hepatocellular; Contrast Enhanced Ultrasound; Bibliometrics; Artificial Intelligence; Super Resolution Ultrasound
- From: Journal of Clinical Hepatology 2026;42(7):1526-1531
- CountryChina
- Language:Chinese
- Abstract: Hepatocellular carcinoma （HCC） is the most common type of primary liver cancer and has a poor overall prognosis. Contrast-enhanced ultrasound （CEUS） plays a crucial role in the diagnosis， treatment response evaluation， and prognostic evaluation of HCC. This article systematically reviews the literature characteristics， research hotspots， and frontier advances of CEUS in the field of HCC. There has been a gradual increase in annual publication volume in this field， with China ranking first globally in the total number of publications. Highly cited articles mainly focus on clinical guidelines and standardized protocols. Keyword analysis shows that the main research hotspots in this field include the diagnosis and standardized assessment of HCC， differential diagnosis， treatment response evaluation after local therapy， and prognostic prediction. Meanwhile， microvascular invasion， artificial intelligence （AI）， and super-resolution ultrasound （SRUS） may be emerging as cutting-edge frontiers in this field. Specifically， AI can be used for the auxiliary diagnosis of HCC， the evaluation of tumor biological characteristics， and prognostic prediction， and SRUS can overcome the acoustic diffraction limit to achieve precise microvascular imaging of the liver. Currently， a solid foundation has been established for the research on CEUS in HCC， showing a strong orientation toward clinical practice. In the future， emerging technologies such as CEUS-based AI models and SRUS are expected to further promote the development of precise diagnosis and treatment for HCC.
