Immune role of targeting lactate metabolism reprogramming in rheumatoid arthritis
10.19405/j.cnki.issn1000–1492.2026.07.023
- VernacularTitle:乳酸代谢重编程靶向治疗在类风湿性关节炎中的免疫作用
- Author:
Jiaye TONG
1
;
Meijuan ZHENG
2
Author Information
1. First Clinical Medical School， Anhui Medical University， Hefei 230032
2. Department of Clinical Laboratory Diagnostics， Anhui Medical University，Hefei 230032
- Publication Type:Journal Article
- Keywords:
lactic acid metabolism;
rheumatoid arthritis;
immune imbalance;
lactylation modification;
metabolic reprogramming;
immune function;
targeted therapy
- From:
Acta Universitatis Medicinalis Anhui
2026;61(7):1325-1332
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis （RA） is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Recent studies have shown that lactate metabolic reprogramming plays a key role in the pathological process of RA， and the accumulation of lactate in the synovial microenvironment triggers a cascade of immune regulatory effects. These metabolic changes create a self-sustaining cycle of inflammation and tissue damage， leading to progressively worsening disease. Therefore， lactate metabolism has been identified as a therapeutic target. Therapeutic strategies targeting lactate metabolism， such as LDHA inhibitors， targeting PKM2， MCT inhibitors， GPR81 antagonists， lactylation modification regulators， and nanosponges， have shown great potential in restoring immune balance and protecting joint integrity. This review summarizes the mechanisms of lactate metabolism in RA and its therapeutic applications， providing a theoretical basis for the development of novel metabolic intervention therapies.
