Clinical characteristics and risk factors of sepsis-associated acute liver injury
10.19405/j.cnki.issn1000–1492.2026.07.022
- VernacularTitle:脓毒症相关急性肝损伤的临床特点及高危因素
- Author:
Lunbing XU
1
;
Qiang JI
1
;
Min SHAO
1
Author Information
1. Department of Critical Care Medicine， The First Affiliated Hospital of Anhui Medical University， Hefei 230022
- Publication Type:Journal Article
- Keywords:
sepsis;
liver injury;
risk factors;
SOFA score;
diabetes;
mechanical ventilation
- From:
Acta Universitatis Medicinalis Anhui
2026;61(7):1318-1324
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the risk factors for liver injury in sepsis， so as to provide a reference for the diagnosis and treatment of sepsis patients with liver injury. MethodsA retrospective analysis was conducted on the clinical data of 402 patients with sepsis. According to the occurrence of acute liver injury during ICU stay， the patients were divided into a sepsis with liver injury group and a sepsis without liver injury group. Univariate analysis was used to screen clinical indicators potentially associated with liver injury， and a multivariate Logistic regression model was then established to identify the independent risk factors for acute liver injury in sepsis patients. ResultsA total of 229 sepsis patients who met the inclusion criteria were enrolled， among whom 110 cases （48.03%） had liver injury， and 52 patients （47.27%） in the liver injury group died. There were statistically significant differences between the two groups in APACHE Ⅱ score， SOFA score， platelet count， lactate level， fibrinogen content， diabetes mellitus， abdominal infection， vasoactive drug therapy， continuous renal replacement therapy， and mechanical ventilation therapy （P<0.05）. Multivariate Logistic regression analysis showed that SOFA score （OR=1.19， 95%CI： 1.06 - 1.33）， diabetes mellitus （OR=3.27， 95%CI： 1.65 - 6.48）， abdominal infection （OR=2.74， 95%CI： 1.33 - 5.62）， and mechanical ventilation therapy （OR=5.24， 95%CI： 1.58 - 17.41） were independent risk factors. ConclusionDiabetes， mellitus， abdominal infection， SOFA score， and mechanical ventilation therapy are independent risk factors for acute liver injury in sepsis patients.
