Association between insulin resistance and cardiovascular metabolic indicators in middle-aged adults
10.19405/j.cnki.issn1000–1492.2026.07.020
- VernacularTitle:中年人胰岛素抵抗与心血管代谢指标的关联
- Author:
Rui TIAN
1
;
Jie ZHANG
2
;
Ting ZHENG
2
;
Aixia ZHANG
2
;
Xing LIU
2
;
Hao KANG
1
;
Qingfang DENG
1
;
Sufang WANG
1
Author Information
1. Department of Nutrition and Food Hygiene， School of Public Health， Anhui Medical University， Hefei 230032
2. Hongguang Community Healthcare Center， Yaohai District， Hefei 230011
- Publication Type:Journal Article
- Keywords:
insulin resistance;
hypertension;
dyslipidemia;
hyperuricemia;
cardiovascular metabolic risk;
middle-aged population;
Logistic regression
- From:
Acta Universitatis Medicinalis Anhui
2026;61(7):1305-1310
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association between insulin resistance （IR） and cardiovascular metabolic indicators， including blood pressure， blood lipids， and serum uric acid， in a middle-aged population. MethodsBased on the baseline survey of the Hong Sifang cohort of China National Salt Industry Group， a total of 575 participants were included. According to the homeostasis model assessment of insulin resistance， the participants were divided into an IR group （n=116） and a non-IR group （n=459）. Differences between the two groups were compared using the t-test and chi-square test. Multivariate logistic regression analysis was performed to evaluate the associations between IR and abnormalities in metabolic indicators. ResultsA total of 575 participants were included， including 390 men and 185 women， with a mean age of （48.58 ± 5.14） years and a mean body mass index （BMI） of （24.16 ± 2.97） kg/m². Blood pressure， serum uric acid， and blood lipid levels were significantly higher in the IR group than in the non-IR group （P<0.001）. After adjusting for potential confounders including age， sex， and BMI， IR was independently associated with hypertension， dyslipidemia， and hyperuricemia， with odds ratios （OR） and 95% confidence intervals （CI） of 2.57 （1.61-4.09）， 3.81 （2.36-6.17）， and 2.68 （1.53-4.71）， respectively （all P<0.001）. ConclusionInsulin resistance is significantly associated with multiple cardiovascular metabolic risk factors in the middle-aged population. Monitoring IR may contribute to the early prevention and control of cardiovascular diseases.
