Assessing type Ⅰ H.pylori for stratifying colorectal neoplasia risk in a gastroenterology clinic population
10.19405/j.cnki.issn1000–1492.2026.07.018
- VernacularTitle:Ⅰ型幽门螺杆菌对消化内科就诊者结直肠肿瘤风险的预测价值
- Author:
Ye YU
1
;
Xia TIAN
1
;
Meng LIU
1
;
Xiaohong CHEN
1
;
Meng WANG
1
Author Information
1. ［Department of Gastroenterology， Tongren Hospital of Wuhan University （Wuhan Third Hospital）， Wuhan 430060］
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
antibody typing;
colorectal neoplasia;
gastroenterology clinic patients;
risk factors;
risk prediction
- From:
Acta Universitatis Medicinalis Anhui
2026;61(7):1289-1295
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between TypeⅠHelicobacter pylori （H. pylori） infection and the risk of colorectal neoplasms （CRN） in patients attending gastroenterology clinics， and to evaluate its predictive value for CRN in this population. MethodsWe included 2 148 patients presenting to the Department of Gastroenterology， with 677 assigned to the CRN group and 1 471 to the non-CRN group.H.pylori antibody typing was performed using Western blot， with typeⅠdefined as positivity for CagA and/or VacA antibodies， and type II as positivity only for UreA/B antibodies. Statistical analyses included univariate screening， multivariate logistic regression， and receiver operating characteristic （ROC） curve evaluation. ResultsTypeⅠH.pylori seropositivity was significantly more prevalent in the CRN group than in the non-CRN group （54.51% vs 45.62%， Padjust<0.05）. No significant differences were observed for type Ⅱ H.pylorior seronegative subjects. The CRN group had higher proportions of males， hypertension， diabetes， smoking， and alcohol use， as well as elevated body mass index， fasting plasma glucose， triglycerides， and uric acid， along with lower high-density lipoprotein levels （all P<0.05）. Multivariate analysis confirmed typeⅠH.pylori （OR=1.303）， alcohol consumption （OR=2.315）， male （OR=1.592）， and age （OR=1.048） as independent risk factors for CRN. Although type I H.pylori alone showed limited predictive value （AUC=0.544）， a combined model incorporating alcohol use， age， and sex demonstrated significantly improved discriminative ability （AUC=0.681， sensitivity 59.1%， specificity 68.2%）. ConclusionTypeⅠH. pylori infection predicts the risk of CRN in gastroenterology patients. Assessing it can help to optimize the identification of high-risk individuals and inform targeted screening strategies.
