LIGNOCAINE INFUSION FOR NEUROPATHIC ITCH IN PATIENT WITH NEUROFIBROMATOSIS

Nadia Mohd Mustafah; Nadia Mohd Mustafah; Wan Nabilah Nik Nabil; Wan Nabilah Nik Nabil; Awisul Islah Ghazali

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LIGNOCAINE INFUSION FOR NEUROPATHIC ITCH IN PATIENT WITH NEUROFIBROMATOSIS

Author: Nadia Mohd Mustafah ¹ ; Nadia Mohd Mustafah ² ; Wan Nabilah Nik Nabil ¹ ; Wan Nabilah Nik Nabil ³ ; Awisul Islah Ghazali ¹
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1. Pain Management Clinic, Department of Anesthesiology and Intensive Care, Hospital Taiping, 34000 Taiping, Perak, Malaysia
2. Department of Rehabilitation Medicine, Faculty of Medicine, Universiti Teknologi MARA, 47000 Sungai Buloh, Selangor, Malaysia
3. Department of Anesthesiology and Intensive Care, Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Malaysia
Publication Type:Journal Article
Keywords: Neurofibromatosis; Lignocaine; Neuropathic Itch; TrpA1; TrpV1
From: Journal of University of Malaya Medical Centre 2025;28(1):66-68
CountryMalaysia
Language:English
Abstract: LIGNOCAINE INFUSION FOR NEUROPATHIC ITCH IN PATIENT WITH NEUROFIBROMATOSIS:Neurofibromatosis (NF) is an autosomal dominant neurocutaneous disorder. The itchiness suffered by patients with NF is possibly caused by mast cells. However, transient receptor potential ankyrin 1 (TrpA1) and transient receptor potential vanilloid 1 (TrpV1) have been recently discovered as mediators of itchiness and pain in patients with NF. We reported a patient with NF, afflicted by neuropathic pain and itch, despite despite receiving conservative treatment. Herein, we provided the patient lignocaine infusion, which improved her pain and itch score by 50%. Additionally, her sleep quality, ability to perform housework and engagement in leisure activities were improved. This case report highlights the therapeutic value of lignocaine infusion when conservative treatment is ineffective for chronic neuropathic itch in patients with neurofibromatosis through suppressing TrpA1 and TrpV1.
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