Research progress on MDCK cell-based influenza vaccine
10.13200/j.cnki.cjb.004751
- VernacularTitle:MDCK细胞基质流感疫苗的研究进展
- Author:
Lanshu LI
- Publication Type:Journal Article
- Keywords:
Influenza vaccine;
MDCK cell;
Cell substrate
- From:
Chinese Journal of Biologicals
2026;39(08):990-996+1002
- CountryChina
- Language:Chinese
-
Abstract:
Influenza poses a significant global health threat due to its high morbidity and mortality rates.Given the rapid mutation rate of influenza viruses, the WHO recommends annual vaccination for optimal protection.Egg-based vaccine production has long been the predominant method for influenza vaccines.However, traditional egg-derived vaccines have limitations, including potential reductions in vaccine efficacy caused by egg-adaptation mutations affecting viral antigenicity.Consequently, the WHO advises considering appropriate cell-based influenza vaccines as alternatives or supplements to eggbased vaccines.Among available cell substrates, MDCK cells are the most widely utilized for influenza vaccine production.MDCK cells support high-yield propagation of diverse influenza viruses, including avian, swine, and equine strains.This paper reviews the research progress and challenges associated with MDCK cell-based influenza vaccines, encompassing the discovery and application of MDCK cells, cell culture platforms, the immunogenicity and clinical safety of cell-based influenza vaccines.
