Research progress on traditional Chinese medicine for the prevention and treatment of asthenozoospermia based on mitochondrial autophagy
- VernacularTitle:基于线粒体自噬探讨中药防治弱精子症的研究进展
- Author:
Shukun LIN
1
;
Jianshe CHEN
2
;
Bo MEN
2
;
Zhixu CHEN
1
Author Information
1. The Second Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Andrology and Reproductive Medicine Center，Henan Provincial Hospital of Traditional Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
asthenozoospermia;
mitochondrial autophagy;
traditional Chinese medicine;
mechanism;
PINK1/parkin signaling
- From:
China Pharmacy
2026;37(15):2068-2072
- CountryChina
- Language:Chinese
-
Abstract:
Asthenozoospermia is one of the important causes of male infertility， and its etiology is complex. Currently， there are no specific targeted therapeutic drugs available. Mitochondrial autophagy plays a crucial role in the progression of this disease. This article systematically summarizes the classification of mitochondrial autophagy and the mechanisms of mitochondrial autophagy mediated asthenozoospermia， and summarizes the research progress of traditional Chinese medicine monomers and formulas in intervening in asthenozoospermia. The results show that mitochondrial autophagy， as an important component of cellular quality control system， mainly includes two types： ubiquitin-dependent and non ubiquitin dependent. Among them， PTEN induced kinase 1/ Parkin signaling pathway mediated ubiquitin dependent mitochondrial autophagy is the most classic. This pathway can participate in regulating sperm physiological functions by degrading damaged mitochondria， maintaining mitochondrial functional homeostasis， antagonizing sperm mitochondrial damage caused by spermatogenesis-associated protein 33 abnormalities， and playing a key bidirectional regulatory role in the progression of asthenozoospermia. Traditional Chinese medicine monomers （allicin， eugenol， etc.） and compound formulas （Bushen qiangjing granules， Huangjing zanyu capsules， etc.） can target and activate or inhibit mitochondrial autophagy according to different pathological states， repair damaged mitochondrial function， improve sperm quality and vitality， fully reflecting the unique therapeutic characteristics of traditional Chinese medicine’s dual directional regulation and “balance‑oriented approach”.
