Research progress on mechanism of active ingredients of traditional Chinese medicine in ameliorating skeletal muscle atrophy
- VernacularTitle:中药活性成分改善骨骼肌萎缩的作用机制研究进展
- Author:
Qin JIANG
1
;
Wenya GUO
1
;
Ying ZHOU
2
;
Jian ZHOU
2
;
Zhenyu ZHANG
1
;
Yanchun GONG
1
;
Lihua YAO
1
;
Yuhua LI
1
Author Information
1. School of Life Science，Jiangxi Science & Technology Normal University，Nanchang 330013，China
2. Dept. of Pharmacy，The First Affiliated Hospital of Nanchang University，Nanchang 330006，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
active ingredients;
skeletal muscle atrophy;
protein metabolism;
oxidative stress
- From:
China Pharmacy
2026;37(15):2057-2062
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal muscle atrophy refers to a pathological condition characterized by muscle fiber atrophy as well as decreased muscle mass and muscle strength induced by various predisposing factors. It falls under the category of “flaccidity syndrome” in traditional Chinese medicine， and its pathogenesis is mainly associated with disturbed protein homeostasis， mitochondrial dysfunction and oxidative stress injury. Active ingredients of traditional Chinese medicine exerts synergistic regulatory effects via multiple pathways， thus possessing unique advantages in the clinical prevention and treatment of skeletal muscle atrophy. This paper reviews the mechanisms by which active ingredients of traditional Chinese medicine alleviate skeletal muscle atrophy. Existing studies have demonstrated that such active ingredients can ameliorate skeletal muscle atrophy through multiple approaches： regulating protein metabolic balance （geniposide， matrine， schisandrin A， etc.） and oxidative stress （astragaloside Ⅳ， Gastrodia elata polysaccharide， Angelica sinensis polysaccharide， etc.）， improving mitochondrial function （parthenolide， berberine， curcumin， etc.）， facilitating myogenesis and myogenic differentiation （cucurbitacin Ⅱb， saikosaponin A， saikosaponin D， etc.）， suppressing inflammatory response （ursolic acid， triptolide， emodin， etc.）， ameliorating insulin resistance （akebiasaponin D， etc.）. In the future， active ingredients of traditional Chinese medicine are expected to achieve breakthroughs in clinical treatment for skeletal muscle atrophy， providing novel ideas and strategies for the prevention and treatment of degenerative disorders.
